Researchers have identified 23 new genetic variants that significantly increase men’s risk of developing prostate cancer.
Believed to be the largest meta-analysis of its kind, pooling data on over 87,000 men, the study
reveals previously unidentified mutations for prostate cancer among groups of European, African,
Latino and Japanese origin.
“Fifteen variants were identified among men of European ancestry, seven were identified in multi-ancestry
analyses and one was associated with early-onset prostate cancer,” write the authors.
Some of the newly identified variants have already been linked to other cancers.
Together with 76 previously known, the new variants account for a third of the inherited
risk of developing prostate cancer in men of European descent. And, because the mutations are
inherited commonly among populations, they can surface in men with little or no family history of
All 23 of the variants – more specifically known as Single Nucleotide Polymorphisms, or SNPs,
(pronounced “snips”) – that the study identifies are to be found in regions of DNA that do not
code for proteins. This suggests they are involved in regulating other genes rather than making
The study authors, including two researchers from Johns Hopkins University School of Medicine in
Baltimore, MD, report their findings in the journal Nature Genetics.
Co-author Alan Partin, a professor of urology at Johns Hopkins, says:
Read more at: http://www.medicalnewstoday.com/articles/282709.php