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An unequal burden: prostate cancer in black men is a global concern

How much cancer risk is unacceptable within a community? One in four black men in the UK will develop prostate cancer in their lifetime.

The global burden of prostate cancer is borne disproportionately by black men – who require greater representation in research, according to a new Special Issue published in ecancermedicalscience.

Seven original research articles from the Prostate Cancer Transatlantic Consortium address the global burden of prostate cancer in black men from multiple perspectives, including screening, intervention, and treatment.

“This work will inspire researchers to try and understand what lies behind the increased risk of black men,” says Dr Frank Chinegwundoh of the Barts Health NHS Trust, a contributor to the Special Issue.

Prostate cancer is the second most common cancer in men globally, and the most common male cancer in Africa, the Caribbean, Europe, and North America.
All black men are disproportionately affected by prostate cancer, while African-American and Jamaican men have the highest rate of prostate cancer in the world.

Multiple factors combine to increase this risk, including genetics and socioeconomic status. However, men of African descent are less likely to be able to access necessary healthcare.

Men of African descent are underrepresented in the sampling pools in both laboratory science and clinical research, partially due to the lack of research funding in developing countries.

This collection of articles provides a worldwide perspective that is urgently needed.
“Prostate cancer disproportionately affects Black men of African ancestry globally,” says Dr Folakemi Odedina of the University of Florida, Guest

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Tomato-rich diet lowers prostate cancer risks

Prostate cancer is the second most common cancer in men around the world, but a new study suggests that eating 10 or more portions of tomatoes a week significantly lowers the risk of developing this disease.

Men who ate over 10 portions of tomatoes per week experienced an 18% reduced risk for prostate cancer, according to the new study.

With higher rates in developed countries, many experts believe prostate cancer is linked to a Westernized lifestyle and diet. The new study, published in the journal Cancer Epidemiology, Biomarkers and Prevention, helped the researchers better understand whether following current dietary and lifestyle recommendations reduces risk for this type of cancer.

It is the first study to develop a prostate cancer “dietary index” that includes dietary components linked to reduced prostate cancer, including selenium, calcium and lycopene-rich foods.

Tomatoes are one such food rich in lycopene, which is a carotenoid that gives fruits and vegetables a red color. The naturally occurring chemical has previously been linked to improved blood vessel function in cardiovascular disease patients, as well as an effective treatment for high cholesterol.

According to the researchers – led by Vanessa Er from the University of Bristol in the UK – lycopene also fights off toxins that can damage DNA and cells.

In total, she and her team – which also included researchers from the Universities of Cambridge and Oxford – assessed the diets and lifestyles of 1,806 men with prostate cancer who were between the ages of 50-69, and compared these

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Unique prostate cancer treatment programs could be tailored using RNA sequencing

Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal Genome Biology. Because a tumor’s RNA shows the real time changes a treatment is causing, the authors think this could be a useful tool to aid diagnosis and predict which treatment will most benefit individual cancer patients.

Colin Collins and Alexander Wyatt, and other researchers from the Vancouver Prostate Centre at the Vancouver Coastal Health Research Institute, matched 25 patients’ treatment outcomes with the RNA sequence of their prostate cancer tumors. They suggest that similarities between the RNA of some of the patients’ tumors could open up new avenues of treatment.

Prostate cancer is the fourth most common cancer worldwide, but can be effectively managed. Doctors normally recommend a combination of therapies, because patients’ reaction to treatment varies considerably. The side-effects of these treatments can be significant, so current research is focused around precision medicine – classifying patients on their tumor’s molecular changes, and only giving them the treatments that are expected to be most effective.

To investigate variations between the highest risk cases of prostate cancer, researchers conducted a range of genomic analyses, including sequencing the RNA in 25 patients’ prostate tumors. The RNA molecules direct which proteins the cell produces, so the RNA sequences show how tumor cells behave differently to normal cells.

Alexander Wyatt, Vancouver Prostate Centre, says: “Most genomic sequencing studies have focused on the DNA, which gives us important information about a tumor’s

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U.S. has seen widespread adoption of robot-assisted cancer surgery to remove the prostate

A new study reveals that the U.S. has experienced widespread adoption of robot-assisted prostate removal surgery to treat prostate cancer in recent years. The BJU International study also found that while such surgeries are more expensive than traditional surgeries, their costs are decreasing over time.

In 2001, surgeons began using robotic technologies in operations to remove the prostate. To examine trends in the use of such robotic-assisted radical prostatectomy (RARP) procedures for prostate cancer patients, Steven Chang, MD, MS, of Harvard Medical School, the Dana-Farber Cancer Institute, and Brigham and Women’s Hospital, led a team that analyzed 489,369 men who underwent non-RARP (i.e., open or laparoscopic radical prostatectomy) or RARP in the United States from 2003 to 2010.

During the study period, RARP adoption (defined as performing more than 50 percent of annual radical prostatectomies with the robotic approach) increased from 0.7 percent to 42 percent of surgeons performing radical prostatectomies. Surgeons who performed at least 25 radical prostatectomies each year were more likely to adopt RARP. Also, from 2005 to 2007, adoption was more common among surgeons at teaching hospitals and at intermediate and large-sized hospitals. After 2007, adoption was more common among surgeons at urban hospitals. RARP was more costly, disproportionally contributing to the 40 percent increase in annual prostate cancer surgery expenditures; however, RARP costs generally decreased and plateaued at slightly over $10,000 while non-RARP costs increased to nearly $9,000 by the end of the study.

“Our findings give insights on the adoption of not just robotic technology but future

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Milk Thistle as a Remedy for Cystitis and Psoriasis

Cystitis and Psoriasis – Both Can Be Helped With Milk Thistle Complex
By Joanna Cake

I’m a great fan of herbal and homeopathic remedies and have had much cause to be grateful to them over the years when the synthetic drugs prescribed by various doctors have proved to be of limited value. I started to be affected by cystitis on a regular basis in my early forties.

I became so miserable in my marriage that I took a lover. The downside of something that, otherwise, made me incredibly happy was that the malady often known as ‘Honeymoon Sickness’ came to haunt me with a vengeance. Repeated love-making several times a day over a period of a long weekend would irritate my bladder, leaving me sore and peeing blood.

I could drink gallons of cranberry juice, plus those special sachets that you get from the chemist, and it would only control it. Never actually cause it to be totally gone. Sometimes, I could feel the bacteria moving up into my kidneys and a course of antibiotics from the doctor would be the only solution to this infection. The side effect of repeated antibiotics is a nice dose of thrush and another trip to the chemist for a pessary of ‘that special cream’.

This in turn meant that the balance of the candida bacteria in my vagina was affected and I began to suffer regular break-outs as the sexual activity meant that these bacteria were transferred from my vagina to my urethra, setting up yet another urinary tract infection. It was a vicious circle. Researching on the internet, I found a natural remedy in the form of a teaspoon of bicarbonate of soda mixed with water and drank several pints of the stuff during and after my weekends with my lover.

I started to recognise the symptoms that were the forerunners of a problem. With a hot water bottle on my belly, a couple of paracetamol for the pain and my glass of ‘soda’, I would recuperate on the couch for a few hours until the discomfort had passed and I was ready to participate once more. I knew that I was going to pay big time for the following week when I went home, but I didn’t care. So long as I could enjoy my weekend, I was prepared to put up with it. Because, again, this ‘cure’ only controlled things and the next urinary tract infection was always lurking in the wings. This was never more evident than if I drank too much alcohol (especially champagne) as I would suffer the consequences from this irritant too.

I put up with this state of affairs for a couple of years and then, quite by chance, I discovered Milk Thistle Complex with Boldo. The vicissitudes of my family life had caused me to reach such a stressful mental state that my skin began to erupt in the lesions of psoriasis on my arms, legs and body. I was devastated. The doctor could only prescribe steroid creams, which soothed the current outbreak but didn’t stop any new patches from breaking through. They were like overgrowths of my skin cells, circular, dry and flaky. I had to find something that would pre-empt those eruptions.

The trusty internet was, once more, my friend and I found Milk Thistle. It is a member of the sunflower family and the active ingredient in its seeds is silymarin, which is an antioxidant. This means that it is able to remove toxic chemicals known as free radicals from the body. Free radicals cause cell damage which is the main cause of disease and premature aging.

But, more important than this, milk thistle detoxifies the liver, promoting the regeneration and repair of cells and protecting it from the damaging effects of alcohol and other toxins. In addition, it has been shown to reduce inflammation and decrease excessive skin growth. Whilst it has been reported that it can cause an upset stomach, there are very few known side effects, but you should consult a qualified medical professional before taking any milk thistle supplements.

Purely by chance, the first jar that I found at my local health shop was a ‘complex’. This means that, in addition to milk thistle, it contained tinctures of fresh artichoke leaves, dandelion herb and root, peppermint and another ingredient that I had never come across before – Peumus boldo dried leaf.

Boldo is a South American herb, the dried leaves of which are used to treat urinary tract infections. (Never take the essential oil internally as it is highly toxic!) Within a fortnight of beginning to take a couple of these pills each day, my existing psoriasis had begun to clear up and no new patches had appeared.

Even better, I visited my lover and, despite being given a severe test over several days, my bladder seemed not to be affected in the same way.

Reassessing my life and removing all the areas of stress meant that the psoriasis seems to have disappeared as suddenly as it arrived and taking my Milk Thistle Complex on a regular basis has sorted out my cystitis. If I do feel the symptoms coming on over a weekend with my lover, I take an extra dose and it all returns to normal. Again, you should consult with a qualified medical professional before using any homeopathic supplements.

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For more information on vaginal thrush infections, visit;

If you’re unhappily married and looking for help, go to:

Joanna Cake is a life blogger who writes about health, parenting, sexual relationships and intimacy at Having My Cake and Eating It Too.

Article Source:—Both-Can-Be-Helped-With-Milk-Thistle-Complex&id=3578821

Originally posted 2010-03-03 00:34:57. Republished by Blog Post Promoter