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In Castration Resistant Prostate Cancer, Study Shows Additional Role For Abiraterone In Blocking Tumor Growth

Main Category: Prostate / Prostate Cancer
Article Date: 18 Mar 2013 – 1:00 PDT

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As part of an EU-supported IMI-PREDECT consortium, a Dutch study showed that anti-androgenic properties of the drug abiraterone may provide an additional mechanism of action in blocking tumour growth of castration resistant prostate cancer (CRPC).

The study, which won the first prize for best abstract in oncology at the 28th European Association of Urology (EAU) Congress held in Milan from March 15 to 19, demonstrated that although the use of abiraterone can potentially lead to an accumulation of precursor hormones, its anti-androgenic properties may stop precursor hormone-induced androgen receptor (AR) activation.

“Our results show that high concentrations of androgen precursors can drive CRPC growth through direct activation of (overexpressed) AR and not necessarily via the result of (intratumoural) CYP17-metabolism. This suggests that CRPC may not rely solely on de novo androgen synthesis,” said lead author Dr. Jan Matthijs Moll of the Erasmus Medical Center, Dept. of Urology in Rotterdam, Netherlands.

Men with castration resistant prostate cancer are a difficult group to treat. Although metastatic prostate cancer may respond well to androgen ablation therapy initially, castration resistance usually develops within

Read more at: http://www.medicalnewstoday.com/releases/257752.php

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